Blood sugar fluctuations can have a significant impact on your brain chemistry, contributing to mood swings, irritability, and even clinical depression. When glucose levels drop too low or spike too high, it can lead to emotional volatility, anxiety, or feeling “on edge” for no clear reason. Women may misattribute these symptoms to PMS, work stress, or family issues, but unmanaged blood sugar could be to blame. Depression is also more common in people with diabetes, creating a two-way street of mental and physical health challenges.